IPF Progression

IPF progression1,3

IPF progression chart image

IPF progression and acute IPF exacerbations1,3

IPF progression and acute IPF exacerbations chart image

IPF and FVC decline3,16-20

IPF and FVC decline chart image

FVC can be used as an objective measure of IPF disease progression, and a ≥10% FVC decline over 12 months has traditionally been used as a predictor of mortality risk.1,21-24 One study showed that a ≥10% FVC decline at 12 months was linked to a ≥2.4x greater risk of mortality.24 Another study showed that a 5%-10% decline in FVC at 6 months might indicate increased mortality risk.25

Limited treatment options have made determining an optimal intervention strategy challenging.1 There has been a high need for a treatment option that can effectively slow the progression of IPF.1

Despite medications that have been used to treat IPF, there is a high unmet need for an effective treatment that can slow disease progression.1


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